In a large bowl, combine 16 ounces of ground beef with 1/2 cup of panko breadcrumbs, 1/4 cup of milk, 1 egg, 3 cloves of finely minced garlic, 1/4 cup of finely chopped parsley, 1/4 cup of grated yellow onion, 1/2 cup of finely grated parmesan, 1/2 teaspoon of salt, 1/2 teaspoon of dried Italian herbs, a pinch of black pepper and a pinch of red pepper flakes